Clin Ther 2009;31(10):2249-2257. Wien Klin Wochenschr 2013;125(1-2):8-15. View abstract. BMC.Geriatr. [65][66][67], According to a systemic review, the effects of ginkgo on pregnant women may include increased bleeding time, and there is inadequate information about safety during lactation. Although Ginkgo biloba and other species of the genus were once widespread throughout the world, its range shrank and by two million years ago, it was restricted to a small area of China. Koltai, M., Tosaki, A., Hosford, D., and Braquet, P. Ginkgolide B protects isolated hearts against arrhythmias induced by ischemia but not reperfusion. In ginkgos, as in other plants that possess them, short shoots allow the formation of new leaves in the older parts of the crown. View abstract. View abstract. View abstract. GO Healthy GO Ginkgo 9,000 1-A-Day Vegecapsules support memory and mental alertness and help maintain circulation to the legs, hands and feet. Ye B, Aponte M, Dai Y, et al. Rai GS, Shovlin C, Wesnes KA. A 26-week analysis of a double-blind, placebo-controlled trial of the Ginkgo biloba extract EGb 761 in dementia. High blood pressure in arteries in the lungs (pulmonary hypertension). Modern-day G. biloba grows best in environments that are well-watered and drained,[14]:87 and the extremely similar fossil Ginkgo favored similar environments: The sediment record at the majority of fossil Ginkgo localities indicates it grew primarily in disturbed environments, such as along streams. Alt Ther 2001;7:105. Free Shipping $49+ i. View abstract. Reviews (71) Overview . Wesnes KA, Ward T, McGinty A, Petrini O. An experimental study of the effect of ginkgo biloba extract on the human and rabbit corpus cavernosum tissue. J Arthroplasty 2005;20:125-6. . Bilateral haematoma after rhytidoplasty and blepharoplasty following chronic use of Ginkgo biloba. Blood Coagul Fibrinolysis 2004;15:303â9. Clinical overview. Leaves are green both on the top and bottom[12] and have stomata on both sides. It is one of the best-known examples of a living fossil, because Ginkgoales other than G. biloba are not known from the fossil record after the Pliocene. ", "Draft genome of the living fossil Ginkgo biloba", "Some trees can live for more than 1,000 years and scientists may have figured out why", "Genetic variation of Ginkgo biloba L. (Ginkgoaceae) based on cpDNA PCR-RFLPs: inference of glacial refugia", "Evidence for the persistence of wild Ginkgo biloba (Ginkgoaceae) populations in the Dalou Mountains, southwestern China", https://e360.yale.edu/features/peter_crane_history_of_ginkgo_earths_oldest_tree, "Examples of Plants with Insect and Disease Tolerance", "Ma-Ke Bonsai Care Guide for Ginkgo biloba", "A-bombed Ginkgo trees in Hiroshima, Japan", "Ginkgo biloba extract for essential hypertension: A systemic review", "Ginkgo biloba for acute ischaemic stroke", "Ginkgo biloba for cognitive impairment and dementia". 2009;28(5):553-559. Acute cognitive effects of standardised Ginkgo biloba extract complexed with phosphatidylserine. Wang H, Ng TB. Arzneimittelforschung 1994;44:1005-13. Woelk H, Arnoldt KH, Kieser M, Hoerr R. Ginkgo biloba special extract EGb 761 in generalized anxiety disorder and adjustment disorder with anxious mood: a randomized, double-blind, placebo-controlled trial. J Neurol.Neurosurg.Psychiatry 2012;83(8):821-827. A preliminary double-blind drug vs. placebo study]. Birks J, Grimley Evans J. Ginkgo biloba for cognitive impairment and dementia. Brinkley, T. E., Lovato, J. F., Arnold, A. M., Furberg, C. D., Kuller, L. H., Burke, G. L., Nahin, R. L., Lopez, O. L., Yasar, S., and Williamson, J. D. Effect of Ginkgo biloba on blood pressure and incidence of hypertension in elderly men and women. Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others. Li AL, Shi YD, Landsmann B, et al. Clin Interv Aging 2013;8:975-81. View abstract. View abstract. View abstract. Some medications that increase the chance of having a seizure include anesthesia (propofol, others), antiarrhythmics (mexiletine), antibiotics (amphotericin, penicillin, cephalosporins, imipenem), antidepressants (bupropion, others), antihistamines (cyproheptadine, others), immunosuppressants (cyclosporine), narcotics (fentanyl, others), stimulants (methylphenidate), theophylline, and others. 2004;27(12):2042-2045. View abstract. Gardner CD, Taylor-Piliae RE, Kiazand A, et al. Int Psychogeriatr. È una specie relitta. View abstract. [34][35] Whether native ginkgo populations still exist has not been demonstrated unequivocally, but there is genetic evidence that these Southwestern populations may be wild, as well as evidence that the largest and oldest Ginkgo biloba trees may be older than surrounding human settlements. Gingko has been commonly cultivated in North America for over 200 years and in Europe for close to 300, but during that time, it has never become significantly naturalized.[38]. Lancet 1998;352:36. View abstract. Eur J Ophthalmol. Zhang HF et al. Accordingly, ginkgo retains a prodigious capacity for vegetative growth. Wilderness.Environ.Med 2009;20(1):66-71. In vivo regulation of peripheral-type benzodiazepine and glucocorticoid synthesis by Ginkgo biloba extract EGb 761 and isolated ginkgolides. The spelling pronunciation /ˈɡɪŋkɡoʊ/ is also documented in some dictionaries. View abstract. Beneath the sarcotesta is the hard sclerotesta (the "shell" of the seed) and a papery endotesta, with the nucellus surrounding the female gametophyte at the center. Sticher, O. View abstract. 2003;9(11):2424-2427. Wesnes K, Simmons D, Rook M, Simpson P. A double-blind placebo-controlled trial of Tanakan in the treatment of idiopathic cognitive impairment in the elderly. The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers. View abstract. View abstract. View abstract. Those at risk included individuals with blood circulation disorders and those taking anticoagulants, such as warfarin or antiplatelet medication (e.g. View abstract. The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers. View abstract. Shakibaei F, Radmanesh M, Salari E, Mahaki B. Ginkgo biloba in the treatment of attention-deficit/hyperactivity disorder in children and adolescents. View abstract. Leaves of long shoots are usually notched or lobed, but only from the outer surface, between the veins. Phytomedicine 2014;21(6):888-92. Ginkgo may interact with some conventional medications, including anticoagulants (blood thinners), research reviews show. Ginkgo biloba (L., 1771) è una pianta gimnosperma, unica specie ancora sopravvissuta della famiglia Ginkgoaceae, dell'intero ordine Ginkgoales (Engler 1898) e della divisione delle Ginkgophyta. National Institutes of Health. © Therapeutic Research Faculty 2018. Effectiveness of oral Ginkgo biloba in treating limited, slowly spreading vitiligo. Osteoporosis and vitamin K intake. Some people are sensitive to the chemicals in the sarcotesta, the outer fleshy coating. [53][54], Systematic reviews have shown there is no evidence for effectiveness of ginkgo in treating high blood pressure,[55] menopause-related cognitive decline,[56] tinnitus,[57] post-stroke recovery,[58] or altitude sickness. View abstract. Ann Intern Med 2001;134:344. [Multicenter, randomized, double-blind drug vs. placebo study of the treatment of tinnitus with Ginkgo biloba extract]. However, other research suggests that ginkgo is not beneficial or is less effective than drugs such as nifedipine. View abstract. Ginkgo biloba for intermittent claudication. J Anal Toxicol 2005:755-8. View abstract. The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. Kim, T. E., Kim, B. H., Kim, J., Kim, K. P., Yi, S., Shin, H. S., Lee, Y. O., Lee, K. H., Shin, S. G., Jang, I. J., and Yu, K. S. Comparison of the pharmacokinetics of ticlopidine between administration of a combined fixed-dose tablet formulation of ticlopidine 250 mg/ginkgo extract 80 mg, and concomitant administration of ticlopidine 250-mg and ginkgo extract 80-mg tablets: an open-label, two-treatment, single-dose, randomized-sequence crossover study in healthy Korean male volunteers. Victoire C, Haag-Berrurier M, Lobstein-Guth A, and et al. [17], The fertilization of ginkgo seeds occurs via motile sperm, as in cycads, ferns, mosses and algae. Ginkgo biloba may assist circulation to the peripheral areas of the body such as the legs, hands and feet and maintains the health of the capillaries. A limited number of small trials evaluating use of ginkgo in diabetes have been conducted. Stough C, Clarke J, Lloyd J, Nathan PJ. View abstract. Ginkgo (Ginkgo biloba) is one of the oldest living tree species. Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others. View abstract. Possible subdural hematoma associated with Ginkgo biloba. Pharmaceutical quality of different Ginkgo biloba brands. View abstract. 1. AMIA Annu Symp Proc. Retrospective data analyses of a randomized controlled trial. 2,839 reviews scanned Product comparison table # Product Name Popularity Score Quality Score Sentiment Score Sales Volume; 1: Feminex Female Libido Enhancer Pills by Phi Naturals 9.7 9.2 J Clin Psychopharmacol 2003;23:576-81. View abstract. [27], The scientific name Ginkgo is the result of a spelling error that occurred three centuries ago. View abstract. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. Pharmacopsychiatry 2003;36 Suppl 1:S32-S37. 10.1002/14651858.CD003120.pub3. View abstract. Planta Med 1996;62:548-51. View abstract. Psychopharmacology (Berl) 2000;152:353-61.. View abstract. Research shows that taking a ginkgo extract for 4 weeks can reduce, A movement disorder often caused by antipsychotic drugs (. Int J Neuropsychopharmacol 2001;4:131-4 . JAMA 2002;288:835-40. Zhou, Y. and Zeng, R. [Effects of Ginkgo biloba extract on anticoagulation and blood drug level of warfarin in healthy wolunteers]. Hum.Psychopharmacol. View abstract. 2009;(1):CD003120. Dardano, A., Ballardin, M., Caraccio, N., Boni, G., Traino, C., Mariani, G., Ferdeghini, M., Barale, R., and Monzani, F. The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with iodine-131. Cochrane Database Syst Rev 2005;(4):CD003691. JAMA 12-23-2009;302(24):2663-2670. View abstract. 1997;4(5):240-245. Lin, Y. Y., Chu, S. J., and Tsai, S. H. Association between priapism and concurrent use of risperidone and Ginkgo biloba. It has been placed loosely in the divisions Spermatophyta and Pinophyta, but no consensus has been reached. Zhang, W. F., Tan, Y. L., Zhang, X. Y., Chan, R. C., Wu, H. R., and Zhou, D. F. Extract of Ginkgo biloba treatment for tardive dyskinesia in schizophrenia: a randomized, double-blind, placebo-controlled trial. Early research shows that receiving ginkgo leaf extract plus the drug dipyridamole by IV seems to reduce symptoms in people with pulmonary hypertension. 2007;157(13-14):295-300. J Clin Pharmacol 2006;46:628-34. Spontaneous bleeding associated with Ginkgo biloba: a case report and systematic review of the literature. J Psychiatry Neurosci 2001;26:221-8. View abstract. van Dongen MC, van Rossum E, Kessels AG, et al. Scripnikov, A., Khomenko, A., and Napryeyenko, O. Psychiatry Res. Kurz A, Van Baelen B. Ginkgo biloba compared with cholinesterase inhibitors in the treatment of dementia: a review based on meta-analyses by the Cochrane collaboration. Thyroid 2012;22(3):318-324. View abstract. Ringing in the ears (tinnitus). 2015;43(2):589-603. For cognitive enhancement, take 120-240mg, one to four hours before performance. The effects of Ginkgo biloba extract (LI 1370) supplementation on activities of daily living in free living older volunteers: a questionnaire survey. Phytomedicine 2002;9:442-6. Van Dongen, M., van Rossum, E., Kessels, A., Sielhorst, H., and Knipschild, P. Ginkgo for elderly people with dementia and age-associated memory impairment: a randomized clinical trial. J Ethnopharmacol 2000;71:83-8. Naccarato M, Yoong D, Gough K. A potential drug-herbal interaction between Ginkgo biloba and efavirenz. Ginkgo biloba induced mood dysregulation: a case report. View abstract. View abstract. View abstract. Isolation of flavonoid glycosides from Ginkgo biloba leaves. Extreme examples of the ginkgo's tenacity may be seen in Hiroshima, Japan, where six trees growing between .mw-parser-output .frac{white-space:nowrap}.mw-parser-output .frac .num,.mw-parser-output .frac .den{font-size:80%;line-height:0;vertical-align:super}.mw-parser-output .frac .den{vertical-align:sub}.mw-parser-output .sr-only{border:0;clip:rect(0,0,0,0);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px}1–2 kilometres (1⁄2–1+1⁄4 miles) from the 1945 atom bomb explosion were among the few living things in the area to survive the blast. Lanthony P, Cosson JP. View abstract. Since its seeds are not protected by an ovary wall, it can morphologically be considered a gymnosperm. The flagella/cilia apparatus pulls the body of the sperm forwards. It may act as an antioxidant to slow down Alzheimer disease and interfere with changes in the brain that might cause problems with thinking. Ginkgo can slow blood clotting. Galluzzi S, Zanetti O, Binetti G, et al. View abstract. Before taking ginkgo talk to your healthcare provider if you take any medications that are changed by the liver. Research shows that taking ginkgo extract daily for 10 weeks along with conventional medication does not improve autism symptoms in children. The symptoms are allergic contact dermatitis[49][50] or blisters similar to that caused by contact with poison ivy. Biol.Pharm.Bull. However, taking a specific combination product containing ginkgo, ginseng, damiana, L-arginine, multivitamins, and minerals (ArginMax for Women) for 4 weeks appears to improve sexual satisfaction in women with sexual dysfunction. It is attractive in appearance, but contains butyric acid[15] (also known as butanoic acid) and smells like rancid butter or vomit[16] when fallen. Wettstein A. Cholinesterase inhibitors and Gingko extracts- are they comparable in the treatment of dementia? Circ Cardiovasc Qual Outcomes 2010;3:41-7. [19] The sperm have a complex multi-layered structure, which is a continuous belt of basal bodies that form the base of several thousand flagella which actually have a cilia-like motion. [Effects of Ginkgo biloba extract on 2 models of experimental myocardial ischemia]. View abstract. The pharmacological effects of ginkgo biloba, a plant extract, on the brain of dementia patients in comparison with tacrine. J Int Med Res 1995;23(1):1-8. The popular cultivar ‘Autumn Gold’ is a clone of a male plant. View abstract. Phytomedicine 1999;6:281-3. J Bronchology Interv Pulmonol. Xenobiotica 2012;42(8):784-90. View abstract. View abstract. Research shows that taking a specific ginkgo leaf extract (EGb 761) by mouth for up to 6 years does not reduce blood pressure in older people with high blood pressure. Some research shows that taking ginkgo leaf extract daily for 8 weeks does not improve sexual function in women with sexual arousal disorder. View abstract. Kohler S, Funk P, Kieser M. Influence of a 7-day treatment with Ginkgo biloba special extract EGb 761 on bleeding time and coagulation: a randomized, placebo-controlled, double-blind study in healthy volunteers. Zhu, L., Gao, J., Wang, Y., Zhao, X. N., and Zhang, Z. X. Neuron degeneration induced by verapamil and attenuated by EGb761. Clin Rheumatol. Yang Z, Li W Huang T Chen J Zhang X. Meta-analysis of Ginkgo biloba extract for the treatment of Alzheimer's disease. Properties and interaction of heterologously expressed glutamate decarboxylase isoenzymes GAD(65kDa) and GAD(67kDa) from human brain with ginkgotoxin and its 5'-phosphate. View abstract. Dodge HH, Zitzelberger T, Oken BS, et al. [34], Where it occurs in the wild, it is found infrequently in deciduous forests and valleys on acidic loess (i.e. View abstract. The dose of your diabetes medication might need to be changed. Invest Ophthalmol Vis Sci 1999;40:1191-9. Canevelli M, Adali N, Kelaiditi E, Cantet C, Ousset PJ, Cesari M; ICTUS/DSA Group. Kudolo GB, Delaney D, Blodgett J. View abstract. von Moltke LL, Weemhoff JL, Bedir E, et al. Singh B, Kaur P, Singh GRD, Ahuja PS. J Clin Pharmacol 2001;41:600-11. Am J Clin Nutr 2000;71:1031-2. Vasc Med 2002;7:265-7. View abstract. The efficacy and safety of Ginkgo biloba extract as an adjuvant in type 2 diabetes mellitus patients ineffectively managed with metformin: a double-blind, randomized, placebo-controlled trial. Savaskan E, Mueller H, Hoerr R, von Gunten A, Gauthier S. Treatment effects of Ginkgo biloba extract EGb 761 on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of randomized controlled trials. View abstract. Research suggests that taking a ginkgo leaf extract called EGb 761 twice daily for 10 weeks does not help people with a cocaine addiction. View abstract. Kanji typically have multiple pronunciations in Japanese, and the characters 銀杏 used for ginnan can also be pronounced ginkyō. The current commonly used names are 白果 (bái guǒ), meaning "white fruit", and 銀杏 (yínxìng), meaning "silver apricot". View abstract. Fortschr Med [Supp] 1991;109(107):6-8. [73] The logo of Osaka University has been a simplified ginkgo leaf since 1991 when designer Ikko Tanaka created it for the university's sixtieth anniversary. View abstract. Phase II study of combined 5-fluorouracil/ Ginkgo biloba extract (GBE 761 ONC) therapy in 5-fluorouracil pretreated patients with advanced colorectal cancer. View abstract. N Engl J Med 1997;336:1108. J Cardiovasc.Pharmacol 2011;57(6):721-727. "Ginkgo biloba for intermittent claudication", "Ginkgo biloba extract for age-related macular degeneration", "Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects", "MedlinePlus Herbs and Supplements: Ginkgo (Ginkgo biloba L.)", "Ginkgo biloba Uses, Benefits & Dosage - Drugs.com Herbal Database", "High-Performance Liquid Chromatography-Electrospray Ionization-Mass Spectrometry Study of Ginkgolic Acid in the Leaves and Fruits of the Ginkgo Tree (Ginkgo biloba)", "Food poisoning by Ginkgo seeds through vitamin B, "An antivitamin B6, 4'-methoxypyridoxine, from the seed of Ginkgo biloba L.", https://en.wikipedia.org/w/index.php?title=Ginkgo_biloba&oldid=1024726326, Plants used in traditional Chinese medicine, Short description is different from Wikidata, Articles containing Chinese-language text, Articles with unsourced statements from November 2013, Articles containing Japanese-language text, Articles with unsourced statements from February 2021, Wikipedia articles with multiple identifiers, Creative Commons Attribution-ShareAlike License, This page was last edited on 23 May 2021, at 20:01. Matthews, MK. View abstract. Parsad, D., Pandhi, R., and Juneja, A. Yagmur E, Piatkowski A, Groger A, et al. Janssens, D., Michiels, C., Delaive, E., Eliaers, F., Drieu, K., and Remacle, J. Singh, B., Song, H., Liu, X. D., Hardy, M., Liu, G. Z., Vinjamury, S. P., and Martirosian, C. D. Dangshen (Codonopsis pilosula) and Bai guo (Gingko biloba) enhance learning and memory. Balon R. Ginkgo biloba for antidepressant-induced sexual dysfunction? Available at: www.clinicaltrials.gov/ct/gui/c/r (Accessed 15 June 2000). Hum Psychopharmacol 2002;17:35-44.. View abstract. View abstract. Burschka MA, Hassan HA, Reineke T, et al. Subhan Z, Hindmarch I. Meta-analysis of 11 clinical studies in patients with cerebrovascular insufficiency in old age]. Yakoot M, Salem A, Helmy S. Effect of Memo, a natural formula combination, on Mini-Mental State Examination scores in patients with mild cognitive impairment. The following doses have been studied in scientific research: Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, Antidepressant-induced sexual dysfunction, Attention deficit-hyperactivity disorder (ADHD), Chronic obstructive pulmonary disease (COPD), Chemotherapy-related cognitive impairment, Anxiety. Wien Med Wochenschr 2002;152:423-6. Acute hemolytic anemia in glucose-6-phosphate dehydrogenase deficiency complicated by Ginkgo biloba. View abstract. View abstract. Kleijnen J, Knipschild P. Ginkgo biloba for cerebral insufficiency. It is native to China, Japan, and Korea, but is also now grown in Europe and the United States. Buss K, Drewke C, Lohmann S, et al. Am J Clin Nutr 2000;71:1665S-8S. Actions of Ginkgo Biloba related to potential utility for the treatment of conditions involving cerebral hypoxia. Clinical assessment of potential cytochrome P450-mediated herb-drug interactions. View abstract. View abstract. Psychopharmacol Bull 1998;34:391-7. View abstract. Psychopharmacology (Berl) 2000;151:416-23. J Altern Complement Med 2005;11:433-9. Phytomedicine 1998;5:425-34. Quality of Ginkgo preparations. Planta Med 1986;52(3):235-236. 2009;19(3):331-336. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Do not take ginkgo if you are taking trazodone (Desyrel). Quaranta L, Bettelli S, Uva MG, et al. Gardiner P, Wornham W. Recent review of complementary and alternative medicine used by adolescents. Porsolt RD, Roux S, Drieu K. Evaluation of a ginkgo biloba extract (EGb 761) in functional tests for monoamine oxidase inhibition. Kang BJ, Lee SJ, Kim MD, Cho MJ. [47] In fact ginkgos arrived from China in the 14th century, and a 1990 tree-ring measurement indicated the tree's age to be about 500 years.[7]. View abstract. Some medications increase the chance of having a seizure. View abstract. Trazodone (Desyrel) affects chemicals in the brain. View abstract. Technical report on the toxicology and carcinogenesis studies of Ginkgo biloba extract in F344/N rats and B6C3F1/N mice. Ibuprofen can also slow blood clotting. Han EJ, Park HL, Kim SH. J Sex Marital Ther 2001;27(5):541-549. Vale S. Subarachnoid haemorrhage associated with Ginkgo biloba. Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and Ginkgo biloba extracts in healthy subjects. J Pharm Pharmacol 2004;56:1039-44. View abstract. [33] The closest living relatives of the clade are the cycads,[14]:84 which share with the extant G. biloba the characteristic of motile sperm. View abstract. J Clin Psychiatry 2001;62(11):878-883. View abstract. Inhibition of human cytochromes P450 by components of Ginkgo biloba.
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